General Clinical Chemistry Analyzers and Accessories
Abcam MM-102 (HMTase Inhibitor I x ), 5MG
MW 669.8 Da, Purity >=98%. MM-102 (HMTase Inhibitor IX) is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis. WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GL x -351322, 25MG
MW 431.5 Da, Purity >=98%. GLX-351322 is a potent NADPH oxidase-4 (NOX-4) inhibitor. Displays selectivity for NOX-4 over NOX-2. GLX-351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells (IC₅₀ = 5 μM).
The product is subject to the following: Abcam Restricted Use Statement
Nova Biomedical Corporation Bioprofile Flex PCO2 Electrode, instrument
Bioprofile Flex PCO2 Electrode. BioProfile is a chemistry/cell viability modular instrument that measures up to 15 key cell culture attributes. By combining as many as five separate instruments into one easy-to-use instrument, BioProfile FLEX simplifies workflow and saves time, labor, and operating cost versus multiple instruments.
Abcam Ponesimod, sphingosine-1-phophate receptor agonist, 10MG
MW 461 Da. Ponesimod is a potent agonist of sphingosine-1-phophate receptor. (S1P₁/EDG-1; IC₅₀s = 6, >10,000, 2,068, 1,956, and 142 nM for S1P₁-S1P₅, respectively, in a radioligand binding assay). Selectively activates S1P₁ in a GTPγS assay (EC₅₀s = 5.7, >10,000, 105, 1,108, and 59.1 nM, for S1P₁-S1P₅, respectively).
The product is subject to the following: Abcam Restricted Use Statement
Abcam SIS3, Smad3 inhibitor, 1MG
MW 490 Da, Purity >98%. Potent and selective Smad3 inhibitor. Selectively inhibits TGF-beta 1/ALK5-induced Smad3 phosphorylation. Inhibits the TGF-beta 1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site. Has no effect on Smad2, p38, MAPK, ERK or PI 3-kinase signaling.
The product is subject to the following: Abcam Restricted Use Statement
Abcam V x -745, p38 alpha MAPK inhibitor, 5MG
MW 436.3 Da. Potent, selective p38 alpha MAPK inhibitor (IC₅₀ = 10 nM), with 20-fold selectivity over p38 beta and 1000-fold selectivity over closely related kinases, ERK1 and JNK1-3.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Alvespimycin (17-DMAG) hydrochloride, 100MG
MW 653.2 Da, Purity >99%. A potent Hsp90 inhibitor (IC₅₀ = 62 nM), can bind to the ATP-binding motif and inhibit the protein chaperoning activity.
The product is subject to the following: Abcam Restricted Use Statement
